Skeletal muscle is the primary tissue for glucose disposal, which is regulated primarily by insulin. When insulin binds to its receptors on muscle cells, it stimulates the movement of GLUT4 from within the cell to the cell membrane so that glucose may enter and be dealt with accordingly. Interestingly enough, in healthy individuals, insulin also acts upon the endothelial cells of blood vessels as a vasodilator, and insulin-stimulated blood flow has been shown to account for up to 40% of glucose uptake.
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