SHR

Recently, Lawrence Reynolds of North Dakota State University published an editorial in The Journal of Nutrition in which attention was brought to the challenges associated with feeding the world’s rapidly expanding population. Reynolds writing was a response to a viewpoint put forth late last year by Donald Kennedy of Stanford University, who correctly pointed out that only through agricultural innovation and increased efficiency of food production can we hope to feed a population that is expected to reach nine billion by 2050.

Heart Disease is the leading cause of death in America. The sun-tanning peptide Melanotan II may be the next big drug therapy breakthrough to fight Atherosclerosis, Heart Attack and Chronic Inflammation  Activation of the Melanocortin system appears to help reduce inflammation in arteries and blood vessels that influences the buildup of plaques and stiffness one study showed. When mice prone to developing Atherosclerosis were give Melanotan II for 4 weeks the therapy showed a marked reduction in the buildup of new plaques and reduced systemic markers of inflammation as compared to controls which were given the vehicle only. While this study did not show a reduction in the size of existing plaque lesions it did also show enhanced endothelium-dependant relaxation and improved vascular sensitivity to nitric oxide's effects. Another study looked at the effects of Melanotan II on post-ischemic recovery of the heart after a myocardial infarction and showed some amazing...

We’ve all heard the benefits of eating bone broth. But there may come a time when you want a cup but don’t have the time to prepare it. Here’s a down and dirty alternative that takes minutes to make and you can even make a single serving! You’ll need to have two things on hand. A quart of Low Sodium Organic Chicken Stock and a canister of Great Lakes Collagen Hydrolysate Protein Powder. Easy stuff next. Warm a serving of Organic Chicken Stock however you like. Stove top or microwave. Once it’s very hot add 2 to 4 tablespoons of Collagen Hydrolysate depending upon how much protein you want. It’s approximately 6 grams of protein per rounded tablespoon. Stir well and done. I know the bone broth aficionados will complain that this is not the same thing as real bone broth and I agree. But hey.. Sometimes you have to make...

Fasting can take a variety of forms. One such is alternate day fasting (ADF) in which individuals do exactly as the name states, alternate fasting and feeding days. Although this originally encompassed not eating for the entire day and creating a roughly 36 hour fast from dinner one night to breakfast two days after, a more prudent version involves only fasting until dinner the following day, about 24 hours. This form of ADF has a strong track record for aiding weight loss and reducing cardiometabolic risk in normal-weight and overweight-obese persons alike. However, although compliance in these and other trials has been exceptional with few reported adverse effects, concerns about the safety of ADF have yet to be directly addressed.

Although we are quite some time away from cranberry season (mid-September to med-November), cardiometabolic diseases such as cardiovascular disease (CVD), type-2 diabetes (T2D), and stroke take lives year-round. The bring this up because a fairly recent review article on cranberries and human health concluded that,

“There is strong experimental evidence that cranberry bioactives have favorable effects on blood pressure, glucose metabolism, lipoprotein profiles, oxidative stress, inflammation, and endothelial function.”

There is no shortage of research showing the consumption of added sugars, especially those from sugar-sweetened beverages (SSB), to be detrimental to health. This of course hasn’t stopped Americans, with adults consuming ~14% and children consuming ~16% of their daily calories as added sugars. These average levels of intake correspond to an 18% increased risk of cardiovascular disease (CVD) mortality. But at what point does the CVD risk really take off? Is there a threshold of sugar consumption where detriments start to accumulate exponentially? To help answer these questions, Kimber Stanhope et al. from the University of California, Davis, investigated the effects of consuming different doses of added sugars from SSBs on CVD risk factors of young and otherwise healthy men and women.

Ketosis is an interesting physiological state characterized by an excessive reliance on fatty acids as an energy source. Under ketogenic conditions, the liver metabolizes fatty acids into two primary ketones: acetoacetic acid and beta-hydroxybutyric acid. A third type of ketone called acetone is also made through the spontaneous breakdown of acetoacetic acid and easily travels into the lungs to be exhaled, thus giving the classic fruity breath of ketosis.

Skeletal muscle is the primary tissue for glucose disposal, which is regulated primarily by insulin. When insulin binds to its receptors on muscle cells, it stimulates the movement of GLUT4 from within the cell to the cell membrane so that glucose may enter and be dealt with accordingly. Interestingly enough, in healthy individuals, insulin also acts upon the endothelial cells of blood vessels as a vasodilator, and insulin-stimulated blood flow has been shown to account for up to 40% of glucose uptake.

Dietary protein and dairy are two very popular topics in the weight loss and metabolic health department. It is well-known that high-protein diets may augment the beneficial effects of calorie restriction so as to preserve more lean body mass (LBM), increase fat-mass losses, and increase satiety during a time a deprivation. Most dairy products are not only full of high-quality protein, but may work through several mechanisms to protect against metabolic syndrome. Interestingly, even when the protein content of the diets is held constant, substitution of yogurt for other foods has been shown to lead to significantly greater reductions in fat mass.

Cognitive decline is one of the hallmarks of age-related degeneration, and emerging research over the last two decades has made considerable advancements in studying how diet influences cognition. It is important to note that cognition spans many areas of brain function, but one tool commonly used to assess the impairment seen in Alzheimer’s disease is short-term memory recall. One very popular dietary product at the moment is dairy food, and significant associations have previously been reported between high dairy product intake and high cognitive ability, including short-term memory, in U.S. citizens. Similarly, dairy intake has been associated with a reduced risk of dementia in Japanese populations.