Energy restriction and weight loss lead to several fundamental changes in physiology that make weight regain easy and continued dieting more difficult. A lot of it comes down to the p-ratio of the dieting individuals, but one hormone that is central to the puzzle is leptin. That is because leptin levels decline both during dieting and after there is a return to caloric maintenance regardless of the weight-loss protocol. The suppression post-dieting is one aspect that makes maintaining a lower body weight so difficult. Interestingly, administration of exogenous leptin during this time has been shown to reverse the reduction in energy expenditure, the reduction in neuromuscular adaptations, and the increased food-reward cues. This begs the question, to what extent does leptin influences these changes? The answer comes from the work of Stefan Camps at Maastricht University, the Netherlands. He and his colleagues recruited 82 obese but otherwise healthy middle-aged men and...
